In this video, Jonas Paludo, MD, Mayo Clinic, Rochester, MN, discusses the challenges and management of adverse events (AEs) related to CAR-T therapy, including cytokine release syndrome (CRS) and neurotoxicity. Dr Paludo first comments on how the management of CRS has improved over the years, and then goes on to discuss treatment options for patients who progress after CAR-T therapy, including bispecific antibodies and antibody-drug conjugates (ADCs). This interview took place at the 11th International Workshop on Waldenström’s Macroglobulinemia (IWWM-11), held in Madrid, Spain.
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