ASH 2023 | LINKER-MM1: promising safety and efficacy of linvoseltamab in R/R multiple myeloma
Hans Lee, MD, The University of Texas MD Anderson Cancer Center, Houston, TX, shares findings from the LINKER-MM1 study (NCT03761108), evaluating step-up dosing of linvoseltamab in relapsed/refractory (R/R) multiple myeloma (MM). After a median follow-up of 8.1 months, the overall response rate (ORR) was 69%, with an estimated 9-month duration of response (DoR) being 87% and a 9-month progression-free survival (PFS) of 73%. There were no new safety concerns, with cytokine release syndrome (CRS) being mainly low-grade and manageable. This interview took place at the 65th ASH Annual Meeting and Exposition, held in San Diego, CA.
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Disclosures
Celgene: Consultancy; AbbVie: Consultancy; Janssen: Consultancy, Research Funding; Amgen: Research Funding; Regeneron: Consultancy, Research Funding; Allogene Thereapeutics: Consultancy; Takeda Pharmaceuticals: Consultancy, Research Funding; Monte Rosa Therapeutics: Consultancy; Pfizer: Consultancy; Sanofi: Consultancy; GlaxoSmithKline: Consultancy, Research Funding; Genentech: Consultancy; Bristol Myers Squibb: Consultancy, Research Funding.
