ASH 2022 | Novel agents vs. standard chemotherapy for first-line salvage treatment following CAR-T in LBCL
Gloria Iacoboni, MD, Vall d’Hebron University Hospital, Barcelona, Spain, presents results from a retrospective multicenter study assessing first-line salvage treatments for patients with large B-cell lymphoma (LBCL) progressing after CAR-T therapy. Four salvage treatments were used, including standard chemotherapy (CT), rituximab-polatuzumab-bendamustine (POLA), bispecific antibodies (BiTEs) and immune checkpoint inhibitors (ICIs). The study demonstrated that salvage therapy with polatuzumab-containing regimens and bispecific antibodies yielded higher response rates and improved progression-free survival (PFS). To conclude, Dr Iacoboni comments on the importance of considering potential toxicities associated with these treatment approaches. This interview took place at the 64th ASH Annual Meeting and Exposition congress held in New Orleans, LA.
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