Speaking from the 2018 Society of Hematologic Oncology (SOHO) Annual Meeting in Houston, TX, William Wierda, MD, PhD, of the MD Anderson Cancer Center, Houston, TX, discusses his group’s 29-gene panel for genetically screening chronic lymphocytic leukemia (CLL) patients. He demonstrates how genetic data can be compared to treatment outcome, in order to illuminate the relationship between the CLL mutational landscape and treatment efficacy.