Rafael de la Cámara, MD, Hospital de la Princesa, Madrid, Spain, shares an update on recent advances regarding the treatment of Epstein-Barr virus–positive post-transplant lymphoproliferative disease (EBV-PTLD). Whilst the use of pre-emptive therapy with rituximab significantly decreases the EBV-PTLD mortality rate, it is not a suitable treatment option for patients who are rituximab-refractory. Dr Cámara reports that recently adoptive cellular immunotherapy with Epstein-Barr virus (EBV)-specific cytotoxic T-lymphocytes (CTL) has enabled the treatment of these patients. This interview took place at the 4th Annual Meeting of the International Academy for Clinical Hematology (IACH), which took place virtually in 2021.