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BSH 2022 | The safety and efficacy of tirabrutinib and entospletinib with or without obinutuzumab in R/R CLL

In this video, Barbara Eichhorst, MD, University Hospital Cologne, Cologne, Germany, shares some results from a Phase II trial investigating the safety and efficacy of entospletinib and tirabrutinib with or without obinutuzumab for the treatment of patients with chronic lymphocytic leukemia (CLL). Unfortunately, this combination of agents did not result in higher rates of complete response or undetectable measurable residual disease (uMRD), and suggest that venetoclax-based combinations may be more effective for patients with CLL. This interview took place at the 62nd Annual Scientific Meeting of the British Society for Haematology (BSH) 2022, in Manchester, UK.


I receive honoraria for presentations and advisory board from several different pharmaceutical companies involved in targeted agents in CLL (Abbvie, BeiGene, BMS, Gilead, Janssen, MSD, Roche).

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