Dennis Eichenauer, MD, University Hospital of Cologne, Cologne, Germany, outlines novel approaches in Hodgkin lymphoma, including the use of anti-PD-1 antibodies in the first-line, as well as anti-CD25 directed approaches as discussed at the virtual Update on Hodgkin Lymphoma organized by the International Symposium on Hodgkin Lymphoma (ISHL). This interview took place at the Update on Hodgkin Lymphoma 2021, a Virtual ISHL event.