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David Sallman, MD, H. Lee Moffitt Cancer Center, Tampa, FL, outlines the significance of mutant p53 in acute myeloid leukemia (AML), and the clinical characteristics associated with this mutational profile, including 10-30% blast state, cytogenetic complexity, and severe pancytopenia. This interview was recorded via an online conference call with The Video Journal of Hematological Oncology (VJHemOnc).