At the 20th Congress of the European Hematology Association (EHA), Paolo Ghia, MD, PhD, of Università Vita-Salute San Raffaele, Milan, Italy, discusses the results of clinical trials of anti-CD20 monoclonal antibodies in combination with chloramubucil, obinutuzumab plus chloramubucil and ofatumumab plus chlorambucil, for first-line therapy in older patients with chronic lymphocytic leukemia (CLL).