Sigrid Skånland, PhD, Oslo University Hospital, Oslo, Norway, briefly summarizes methods to prevent resistance to targeted therapies in chronic lymphocytic leukemia (CLL). Dr Skånland draws focus on one strategy, which is to target several pathways by combining different agents, such as venetoclax and ibrutinib. Dr Skånland concludes by mentioning the possibility of using fixed duration therapy in treatment, and the benefits of this method of treatment in cases of relapsed disease. This interview took place during the 2nd ESH Translational Research Conference on Chronic Lymphocytic Leukemia (ESH CLL), 2022.