Rami Komrokji, MD, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, explores the rationale and trial design of a Phase I study evaluating LB-100, a phosphatase inhibitor, in low and intermediate-risk myelodysplastic syndrome (MDS) patients with or without deletion 5q, a common genetic abnormality in MDS. This interview was recorded via an online conference call with The Video Journal of Hematological Oncology (VJHemOnc).