In this video, Nicholas Short, MD, The University of Texas MD Anderson Cancer Center, Houston, TX, briefly discusses the role of transplantation in patients with newly diagnosed Ph+ acute lymphoblastic leukemia (ALL) treated with ponatinib and blinatumomab. Dr Short highlights how the treatment of patients may shift away from transplant and focus on chemotherapy-free regimens. This interview took place at the European Hematology Association (EHA) Congress 2022 held in Vienna, Austria.