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IMS 2024 | Treating relapsed myeloma outside of the use of T-cell redirected therapies
P. Joy Ho, MBBS, DPhil, FRACP, FRCPA, FFSc(RCPA), Royal Prince Alfred Hospital & University of Sydney, Sydney, Australia, discusses the treatment of relapsed multiple myeloma (MM) outside of the use of T-cell redirected therapies, noting that treatment decisions are heavily influenced by patients’ refractoriness to lenalidomide, proteasome inhibitors, and anti-CD38 antibodies. Prof. Ho emphasizes the efficacy of anti-CD38 antibody triplet combinations for lenalidomide-refractory patients, while other options, including carfilzomib- or pomalidomide-based combinations and emerging therapies like cereblon E3 ligase modulators (CELMoDs), may be suitable for those also refractory to anti-CD38 antibodies. This interview took place at the 21st International Myeloma Society (IMS) Annual Meeting, held in Rio de Janeiro, Brazil.
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