Here, Stanley Riddell, MD, of Fred Hutchinson Cancer Research Center, Seattle, WA., speaks about the promising results with CD19-targeted CAR T-cell therapy for relapsed/refractory (R/R) B-cell acute lymphoblastic leukemia (B-ALL), non-Hodgkin lymphoma (nHL) and chronic lymphocytic leukemia (CLL). Dr Riddell also addresses the issue of relapse in certain populations of patients, stressing the need to identify alternative targets and improve persistence. Dr Riddell was speaking at the 1st European CAR T-Cell Meeting, held in Paris, France, co-organized by the European Society for Blood & Marrow Transplantation (EBMT) and European Hematology Association (EHA).