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CAR-T Meeting 2024 | Engineering molecular ON- and OFF-switches for controlling CAR T-cells

Charlotte Zajc • 16 Feb 2024
CAR-T Meeting 2024
General CAR-T

Charlotte Zajc, PhD, University of Natural Resources and Life Sciences, Vienna, Austria, explores the engineering of molecular ON- and OFF-switches to regulate CAR T-cells. Utilizing small molecule drugs, these switches can effectively modulate cytokine secretion, cytotoxicity, and CAR signaling. This strategy aims to prevent T-cell exhaustion and enhance the persistence of CAR T-cell therapies. This interview took place at the EBMT-EHA 6th European CAR T-cell Meeting in Valencia, Spain.

These works are owned by Magdalen Medical Publishing (MMP) and are protected by copyright laws and treaties around the world. All rights are reserved.

Disclosures

Patent related to ON-switches. Funding received by Miltenyi Biotec.

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Charlotte Zajc • 16 Feb 2024

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