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ICML 2023 | Brentuximab vedotin-nivolumab alone and then with R-CHP as frontline therapy for PMBCL

Raphael Steiner, MD, The University of Texas MD Anderson Cancer Center, Houston, TX, discusses a trial investigating brentuximab vedotin plus nivolumab alone and then in combination with rituximab-cyclophosphamide-doxorubicin-prednisone (R-CHP) as frontline therapy for patients with primary mediastinal large B-cell lymphoma (PMBCL; NCT04745949). Dr Steiner describes the structure of the regimen, and shares data regarding the efficacy and safety of the treatment so far. Dr Steiner notes the occurrence of immune-related adverse events (AEs), which were managed with the use of dexamethasone. This interview took place at the 17th International Conference on Malignant Lymphoma (ICML), held in Lugano, Switzerland.

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Research funding: Seagen, BMS, GSK, Rafael Pharmaceuticals