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COMy 2024 | The role of the peptide-drug conjugate melflufen in multiple myeloma

Enrique Ocio • 25 May 2024
COMy 2024
Multiple Myeloma Dexamethasone Melflufen Melphalan Pomalidomide
OCEAN

Enrique Ocio, MD, PhD, Marquis of Valdecilla University Hospital, Santander, Spain, discusses melphalan flufenamide (melflufen), a peptide-drug conjugate approved in Spain for treating multiple myeloma. After a 30% response rate in a Phase II trial, the Phase III OCEAN study (NCT03151811) compared melflufen plus dexamethasone to pomalidomide plus dexamethasone. The trial showed that melflufen improved progression-free survival (PFS) and had a favorable safety profile. Its convenient administration and potential for combination therapy make melflufen a valuable addition to myeloma treatment. This interview took place at The 10th World Congress on Controversies in Multiple Myeloma (COMy) in Paris, France.

These works are owned by Magdalen Medical Publishing (MMP) and are protected by copyright laws and treaties around the world. All rights are reserved.

Disclosures

Honoraria/Consultancy: Janssen, BMS, Sanofi, GSK, Oncopeptides, Amgen, Takeda, Secura-Bio, MSD, Mundipharma-EDO.

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