Loretta Nastoupil, MD, University of Texas MD Anderson Center, Houston, TX, shares some insights into the controversies surrounding the management of lymphomas, drawing focus on the numerous studies being conducted and how treatment practices are quickly changing. Dr Nastoupil highlights some of the novel therapies being made available, including CAR-T and bispecific antibodies, and the challenges that clinicians face with interpreting this novel data and ensuring that the best treatment decisions are made for each lymphoma sub-type. This interview took place at the 63rd ASH Annual Meeting and Exposition congress in Atlanta, GA, 2021.