ESH AL 2026 | Defining AYA ALL: how this varies across different countries
Wendy Stock, MD, University of Chicago Medical Center, Chicago, IL, comments on the definition and age range of adolescent and young adult acute lymphoblastic leukemia (AYA ALL), noting that it varies by country. This interview took place at the 5th How to Diagnose and Treat: Acute Leukemias meeting of the European School of Hematology (ESH AL) in Mandelieu-La Napoule, France.
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Transcript
The definition of AYA-ALL is very country-dependent, I would say. And in North America, AYA-ALL is defined by the National Cancer Institute, in the U.S. anyway, as patients 18 to 40 years old, up to age 40. That’s the group that we’ve studied as AYA patients. And I think some of the discussion today surrounding that is a very relevant conversation because there are clearly some older patients who can tolerate that kind of intensive therapy that is given to an AYA patient...
The definition of AYA-ALL is very country-dependent, I would say. And in North America, AYA-ALL is defined by the National Cancer Institute, in the U.S. anyway, as patients 18 to 40 years old, up to age 40. That’s the group that we’ve studied as AYA patients. And I think some of the discussion today surrounding that is a very relevant conversation because there are clearly some older patients who can tolerate that kind of intensive therapy that is given to an AYA patient. And there are patients in the AYA range who can’t tolerate that therapy because of biological comorbidities. And in different countries in the world, it’s different. Some places it’s ages 15 to 30. In the US, I think I said 18 to 40, but those are what the adult trials use. But AYA, ALL is defined as age 15 to up to age 40.
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