ASH 2024 | Azacitidine, venetoclax & magrolimab in patients with newly diagnosed & R/R high-risk AML
Sankalp Arora, MD, The University of Texas MD Anderson Cancer Center, Houston, TX, comments on the results of a Phase Ib/II clinical trial evaluating the combination of azacitidine, venetoclax, and magrolimab in patients with newly diagnosed and relapsed/refractory (R/R) high-risk acute myeloid leukemia (AML). Dr Arora highlights the encouraging response rates observed, with a composite complete response of approximately 90% in TP53 wild-type patients and 49% in TP53-mutated patients, but notes that survival outcomes were disappointing, with a median overall survival (OS) of around 10 months for the entire cohort. Dr Arora then goes on to summarize data from single-cell sequencing of the TP53-mutated samples. This interview took place at the 66th ASH Annual Meeting and Exposition, held in San Diego, CA.
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