Rachel Rau, MD, of Baylor College of Medicine, Houston, TX, discusses the optimal use of blinatumomab for the treatment of B-cell acute lymphoblastic leukemia (B-ALL), commenting on how it could be used to achieve undetectable measurable residual disease (MRD). Dr Rau also talks on the Phase III AALL1731 trial (NCT03914625) currently investigating blinatumomab in combination with chemotherapy for newly diagnosed (B-ALL). This interview took place during the ninth annual meeting of the Society of Hematologic Oncology (SOHO 2021) congress.