Rachel Rau, MD, of Baylor College of Medicine, Houston, TX, gives an overview of the latest findings from research into the therapeutic use of bispecific T-cell engagers (BiTEs) for the treatment of B-cell acute lymphoblastic leukemia (B-ALL), in particular blinatumomab. Dr Rau comments on trials exploring blinatumomab both in the adult and pediatric settings, in particular highlighting the AA1331 trial (NCT02101853). Dr Rau also talks on a trial exploring the use of nivolumab in combination with blinatumomab to enhance blinatumomab’s efficacy, and comments on the challenges of treating B-ALL linked to Down Syndrome. This interview took place during the ninth annual meeting of the Society of Hematologic Oncology (SOHO 2021) congress.