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CAR-T Meeting 2025 | The potential role of the tumor microenvironment in CAR T-cell therapy
In this video, Ulrich Jäger, MD, Medical University of Vienna, Vienna, Austria, briefly comments on the potential role of the tumor microenvironment in CAR T-cell therapy, highlighting that targeting the tumor cell alone is likely not sufficient to optimize outcomes. Prof. Jäger expresses his excitement over novel approaches being developed to modulate macrophages in the microenvironment of both solid tumors and hematological malignancies. This interview took place at the EHA-EBMT 7th European CAR T-cell Meeting, held in Strasbourg, France.
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Transcript (AI-generated)
One of the most exciting developments I thought at this meeting was the developments in the solid tumors and what we learn there which can also be applied for lymphomas, for instance, is that it’s not only important to target the tumor cell but that the microenvironment prohibits the CARs from doing their work. And we’ve seen some very exciting approaches like how can you hijack the macrophages or how can you eliminate macrophages in the tumor in order to make treatments work and I thought that that was one of the most exciting works that I have seen from several groups...
One of the most exciting developments I thought at this meeting was the developments in the solid tumors and what we learn there which can also be applied for lymphomas, for instance, is that it’s not only important to target the tumor cell but that the microenvironment prohibits the CARs from doing their work. And we’ve seen some very exciting approaches like how can you hijack the macrophages or how can you eliminate macrophages in the tumor in order to make treatments work and I thought that that was one of the most exciting works that I have seen from several groups.
This transcript is AI-generated. While we strive for accuracy, please verify this copy with the video.
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