Ryan Cassaday, MD, University of Washington, Seattle, WA, discusses blinatumomab’s place in the acute lymphoblastic leukemia (ALL) treatment landscape, highlighting its role in relapsed/refractory (R/R) disease, its future in the frontline setting, and the promise of combinations with other agents, including dasatinib and ponatinib. This interview took place at the European Hematology Association (EHA) Congress 2022 held in Vienna, Austria.