Loretta Nastoupil, MD, University of Texas MD Anderson Center, Houston, TX, discusses the results of the phase II trial (NCT01582776) of obinutuzumab, a monoclonal antibody glycoengineered for enhanced antibody-dependent cellular cytotoxicity (ADCC), with lenalidomide in previously untreated, high tumor burden follicular lymphoma (FL). This drug combination was associated with high complete response and manageable toxicities. This interview took place at the American Society of Hematology (ASH) 2019 Annual Meeting and Exposition in Orlando, FL.