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Tandem Meetings 2023 | Incorporating immunotherapy in the frontline & salvage treatment of Hodgkin lymphoma

Swetha Kambhampati, MD, City of Hope, Duarte, CA, comments on the benefit of adding novel agents such as brentuximab vedotin and checkpoint inhibitors like nivolumab into the frontline treatment of Hodgkin lymphoma (HL). The ECHELON-1 (NCT01712490) study reported an overall survival (OS) advantage for patients treated with A+AVD (brentuximab vedotin, doxorubicin, vinblastine, and dacarbazine) when compared to ABVD (doxorubicin, bleomycin, vinblastine, and dacarbazine) alone. An ongoing study (NCT03907488) is now comparing brentuximab vedotin or nivolumab with chemotherapy in HL. Dr Kambhampati also comments on the benefit of these immunotherapeutic agents in the salvage setting, where they have been shown to improve chemosensitivity. This interview took place at the 2023 Transplantation & Cellular Therapy Meetings of ASTCT™ and CIBMTR® held in Orlando, FL.

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