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IWWM-12 2024 | BTKis in WM: ibrutinib versus zanubrutinib and the use of non-covalent BTKis

Marek Trněný, MD, PhD, Charles University Hospital, Prague, Czech Republic, discusses the evolution of BTK inhibitors (BTKis) in the Waldenström’s macroglobulinemia (WM) treatment landscape. He compares the efficacy and tolerability of zanubrutinib and ibrutinib, and considers the potential use of pirtobrutinib after covalent BTKi failure. This interview took place at the 12th International Workshop on Waldenström’s Macroglobulinemia (IWWM-12) in Prague, Czech Republic.

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Disclosures

Advisory Board: Roche, Takeda, Gilead, Abbvie, Caribou, GenMab, BMS, Janssen, Morphosys, Novartis, SOBI, Autolus; Research Support: Roche; Honoraria: Roche, Takeda, Gilead, Abbvie, SOBI, Caribou, Autolus, GenMab, Janssen.