In this video, Jianxiang Wang, MD, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, talks on CAR-T therapy for the treatment of acute lymphoblastic leukemia (ALL). Dr Wang discusses the need to reduce the risk of relapse following CD19 CAR-T therapy and describes ongoing trials investigating CD22/CD19 CAR-T sequential therapy, which demonstrate high efficacy and a prolonged duration of remission. This interview took place at the European Hematology Association (EHA) Congress 2022 held in Vienna, Austria.