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IMS 2024 | Challenges that remain regarding the use of cfDNA for MRD detection in myeloma: cost and sensitivity
Dory Abelman, PhD(c), Princess Margaret Cancer Centre, Toronto, Canada, discusses the key challenges in using circulating cell-free DNA (cfDNA) for measurable residual disease (MRD) detection in multiple myeloma (MM), highlighting the high cost of sequencing and bioinformatics and the need for improved sensitivity to distinguish between benign mutations and those associated with malignancy. Efforts to enhance sensitivity accuracy include analyzing nucleosome accessibility and DNA fragment length, which may refine MRD-guided treatment strategies and improve patient outcomes. This interview took place at the 21st International Myeloma Society (IMS) Annual Meeting, held in Rio de Janeiro, Brazil.
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