Joaquin Martinez-Lopez, MD, PhD, of the Universidad Complutense de Madrid, Madrid, Spain, gives an overview of the unmet needs in the treatment of chronic myeloid leukemia (CML). Dr Martinez-Lopez focuses on two main clinically unmet needs: long-term toxicities and treatment resistance in CML, and explains how future research may address these. This interview took place during the 18th International Myeloma Workshop (IMW 2021) congress.