Selina Luger, MD, University of Pennsylvania, Philadelphia, PA, gives an update on current trials investigating the effectiveness of non-cytotoxic therapies for treating elderly patients with acute lymphoblastic leukemia (ALL). These therapies include inotuzumab, venetoclax, blinatumomab and dasatinib. This interview took place during the 2021 European School of Hematology (ESH) 2nd Translational Research Conference on Acute Lymphoblastic Leukemia.