David Marks, MBBS, PhD, FRACP, FRCPath, University Hospitals Bristol NHS Foundation Trust, Bristol, UK, shares upcoming promising clinical trials in the acute lymphoblastic leukemia (ALL) space. The use of blinatumomab, a bispecific antibody that coordinates cytotoxic CD3+ T lymphocytes and CD19+ lymphoblasts, is being evaluated in a randomized trial, and results are awaited with interest. Clinical trials comparing ponatinib and imatinib in Philadelphia chromosome-positive (Ph+) ALL will determine whether ponatinib is a superior treatment agent for Ph+ ALL. This interview took place during the 2021 European School of Hematology (ESH) 2nd Translational Research Conference on Acute Lymphoblastic Leukemia.