Wojciech Jurczak, MD, PhD, Jagiellonian University, Krakow, Poland, comments on the administration of acalabrutinib after allogeneic stem cell transplantation (alloSCT) in patients with chronic lymphocytic leukemia (CLL) or mantle cell lymphoma (MCL). Prof. Jurczak also comments on how the rapid advances in CAR-T cell therapies may impact this. This interview took place at the European Hematology Association (EHA) Congress 2022 held in Vienna, Austria.