Srdan Verstovsek, MD, The University of Texas MD Anderson Cancer Center, Houston, TX, discusses the benefits of pelabresib in combination with ruxolitinib for treatment naïve myelofibrosis. Myelofibrosis patients in Arm 2 of the MANIFEST (NCT04603495) Phase II study of pelabresib for anemia associated with myelofibrosis were not achieving adequate benefit from treatment with ruxolitinib, so were treated with pelabresib as add-on. In transfusion dependent (TD) patients, 36% of patients achieved transfusion independence (TI). In non-TD patients, 17.4% of patients achieved a mean hemoglobin (Hgb) increase ≥1.5g/dL sustained over a 12-week transfusion-free period. This interview took place at the virtual European Hematology Association (EHA) Congress 2021.