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SOHO 2022 | Looking beyond BCL-2 inhibition in AML: the potential role of MCL-1 inhibitors and BCLxL inhibitors

Marina Konopleva, MD, PhD, Albert Einstein College of Medicine, New York, NY, discusses approaches to treating acute myeloid leukemia (AML) beyond BCL-2 inhibition, drawing focus on MCL-1 and BCLxL inhibition. Prof. Konopleva first explains the importance of investigating other inhibitors outside of venetoclax, especially for patients who develop resistance to this agent. Following this, Prof. Konopleva highlights some agents being investigated and their potential role in the future treatment of AML. This interview took place at the Tenth Annual Meeting of the Society of Hematologic Oncology (SOHO) held in Houston, TX.

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