Mazyar Shadman, MD, Fred Hutchinson Cancer Research Center, Seattle, WA, talks on COVID-19 vaccine recommendations for patients with chronic lymphocytic leukemia (CLL), highlighting potential efficacy limitations associated with disease biology. Dr Shadman also gives an overview of existing data on COVID-19 vaccine efficacy in patients with CLL and shares recommendations for vaccination. This interview took place at the virtual European Hematology Association (EHA) Congress 2021.