In this video, Aaron Gerds, MD, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, discusses the role of ruxolitinib in the treatment of myeloproliferative neoplasms (MPNs), drawing focus on how this agent has transformed the treatment landscape of myelofibrosis (MF). Dr Gerds first provides some background information on the development and approval of ruxolitinib, and then goes on to explain how this agent has greatly improved patient outcomes over the years. This interview took place at the third annual Texas MPN Workshop (TMW) 2022, held in San Antonio, TX.