Angela Fleischman, MD, UCI Health, Orange County, CA, outlines the impact of host, lifestyle and environmental factors in the pathogenesis of myeloproliferative neoplasms (MPNs) and hihglights the role of inflammatory environment in the expansion of mutant hematopoietic cells. This interview was recorded via an online conference call with The Video Journal of Hematological Oncology (VJHemOnc).