Lydia Scarfò, MD, Vita-Salute San Raffaele University & IRCCS San Raffaele Scientific Institute, Milan, Italy, discusses Bruton’s tyrosine kinase (BTK) and phospholipase C gamma 2 (PLCG2) mutations in chronic lymphocytic leukemia (CLL) patients receiving ibrutinib. This interview was recorded via an online conference call with The Video Journal of Hematological Oncology (VJHemOnc).