ASH 2023 | SAR’579, a trifunctional anti-CD123 NK cell engager, in R/R AML, B-ALL, and HR-MDS
Ashish Bajel, MBBS, FRACP, FRCPA, Peter MacCallum Cancer Centre and The Royal Melbourne Hospital, Melbourne, Australia, presents the findings from a first-in-human study (NCT05086315) of SAR443579 (SAR’579), a trifunctional anti-CD123 natural killer (NK) cell engager, in patients with relapsed/refractory (R/R) acute myeloid leukemia (AML), B-cell acute lymphoblastic leukemia (B-ALL) or higher-risk myelodysplastic syndromes (HR-MDS). This agent targets the CD123 antigen on leukemia cells, and leverages NK-cell mediated killing of the cell. To date, the drug has been well tolerated and has led to blast reduction across all dose levels. This interview took place at the 65th ASH Annual Meeting and Exposition, held in San Diego, CA.
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