Jacqueline Cloos, PhD, of Amsterdam UMC, Amsterdam, The Netherlands, talks on the role of measurable residual disease (MRD) as a prognostic factor in the management of acute myeloid leukemia (AML). MRD is a small number of leukemic cells that remain after treatment, which is the major cause of relapse in cancer patients. Prof. Cloos talks on the strengths of MRD as a prognostic factor for the early identification or patients with AML who are at higher risk of relapse during therapy. This interview took place during the ninth annual meeting of the Society of Hematologic Oncology (SOHO 2021) congress.