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AACR 2022 | Differential dynamics of response between axi-cel and tisa-cel in R/R B-cell lymphoma

In this video, Nicholas Haradhvala, PhD, Broad Institute, Cambridge, MA, discusses a recent project in which single-cell RNA sequencing was used to analyze T-cells in patients with refractory B-cell lymphoma and compare responses to axicabtagene ciloleucel (axi-cel) and tisagenlecleucel (tisa-cel). Dr Haradhvala first provides some background information on patient responses to chimeric antigen receptor T-cell (CAR-T) therapies, and then briefly discusses the method used in this study. Dr Haradhvala then explains the differences observed in the dynamics of axi-cel and tisa-cel, and how this influenced patient response to both products. Following this, Dr Haradhvala mentions that single-cell RNA sequencing also allowed investigators to analyze how CAR-T cells work across multiple treatments, and how further analyses with this method may influence future treatment decision-making in patients with B-cell lymphoma. This interview took place at the American Association for Cancer Research Annual Meeting in New Orleans, LA.