This is a fantastic question because we really, as we are having more of these transformative therapies, it is addressing acute pain crises and it’s preventing really the admission to the hospital. And I am hopeful that we will be able to show improvement in some of the end-organ damage that has yet to be seen. But one of the challenges that remain in this patient population is many of them suffer from chronic pain due to the multiple vascular necrosis that they may have, and that is a phenomenon that we really have to better understand...
This is a fantastic question because we really, as we are having more of these transformative therapies, it is addressing acute pain crises and it’s preventing really the admission to the hospital. And I am hopeful that we will be able to show improvement in some of the end-organ damage that has yet to be seen. But one of the challenges that remain in this patient population is many of them suffer from chronic pain due to the multiple vascular necrosis that they may have, and that is a phenomenon that we really have to better understand. So the challenge is addressing that. It needs to be studied better in basic science. We need to understand more about why this chronic pain occurs and how to manage it better because this is not the same management as with opioids that we have. And we have as a physician, to treat this with empathy and to take the stigma out of that by having better research. But also, so many of these patients have mental health disorders, and that is really a problem in our healthcare system. So addressing the chronic pain has to be matched with also managing the mental health disorder and access to a therapist, either a psychologist or psychiatrist, to help us address that.
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