Alessandra Romano, MD, PhD, University of Catania, Catania, Italy, discusses the importance of using multidisciplinary approaches when diagnosing and treating patients with Waldenström’s macroglobulinemia (WM), amyloidosis, and systemic mastocytosis (SM), and further highlights the promise of novel immunotherapeutic approaches. This interview took place at the 4th Society of Hematologic Oncology (SOHO) Italy Annual Conference, held in Rome, Italy.