Alexandra Power-Hays, MD, Cincinnati Children’s, Cincinnati, OH, briefly discusses the development and validation of HdxSim, a clinical decision support tool for model-informed precision dosing (MIPD) of hydroxyurea in children with sickle cell disease (SCD), which has been used to optimize pharmacokinetic (PK)-guided dosing in the ADAPT trial (NCT05662098). This interview took place at the 65th ASH Annual Meeting and Exposition, held in San Diego, CA.
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