Wojciech Jurczak, MD, PhD, Jagiellonian University, Krakow, Poland, shares some insights into the BRUIN CLL-321 study (NCT04666038), evaluating the use of pirtobrutinib versus investigator’s choice for the treatment of chronic lymphocytic leukemia (CLL). Prof. Jurczak highlights the importance of Bruton’s tyrosine kinase (BTK) inhibitors in CLL treatment and the impressive tolerability and low toxicity of pirtobrutinib compared to other agents. This interview took place at the European Hematology Association (EHA) Congress 2022 held in Vienna, Austria.