EHA 2024 | MRD testing prior to alloSCT can predict OS and DFS in AML
Firas El Chaer, MD, University of Virginia, Charlottesville, VA, discusses a study investigating the predictive value of measurable residual disease (MRD) testing by multiparameter flow cytometry (MFC) for patients with acute myeloid leukemia (AML) in the first complete remission (CR1). The study found that MRD testing before allogeneic stem cell transplantation (alloSCT) predicted overall survival (OS) and disease-free survival (DFS), but not treatment-related mortality (TRM). The MRD test had a positive predictive value (PPV) of 45% and a negative predictive value (NPV) of 67%. This interview took place at the 29th Congress of the European Hematology Association (EHA) in Madrid, Spain.
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