This episode features discussions from the 3rd International Workshop on Myelodysplastic Syndromes & Myeloproliferative Neoplasms (iwMDS & iwMPN) 2025, held in Lisbon, Portugal. First, you will hear from Uma Borate, MD, The Ohio State University, Columbus, OH, Luca Lanino, MD, PhD, Yale University, New Haven, CT, Robert Hasserjian, MD, Massachusetts General Hospital, Boston, MA, and Zoey Xie, MD, MS, Moffitt Cancer Center, Tampa, FL, who share updates in the classification and risk stratification of MDS. Hetty Carraway, MD, Cleveland Clinic, Cleveland, OH, and Amy DeZern, MD, MHS, Johns Hopkins University School of Medicine, Baltimore, MD, then go on to discuss novel pathways and therapeutic agents being explored, including telomerase inhibition, the SELECT-MDS-1 study (NCT04797780), and more.