Peter Bader, MD, PhD, Goethe University Frankfurt, Frankfurt, Germany, discusses transplantation in an evolving therapy landscape and how to place CAR-T in the r/r pediatric acute lymphoblastic leukemia (pedALL) treatment algorithm at the 5th International Congress on Controversies in Stem Cell Transplantation and Cellular Therapies (COSTEM) 2019, held in Berlin, Germany.