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ESC 2026 | Insights into the potential of CRISPR-based gene editing in ATTR-CM

Ronald Witteles, MD, Stanford University, Stanford, CA, discusses the potential of CRISPR-based gene editing as a one-time treatment for transthyretin amyloid cardiomyopathy (ATTR-CM), highlighting its ability to achieve sustained TTR reduction. Dr Witteles also explores the key considerations for its future adoption in routine cardiology practice, including efficacy, durability, safety and patient acceptance. This interview took place during the 2026 European Society of Cardiology (ESC) Congress in Munich, Germany.

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